DS Hub strives to establish thought leadership in digital sustainability by developing a holistic approach by which entrepreneurial organizations and communities deploy future-ready digital technologies. This holistic approach begins with a detailed analysis of the complex societal challenges facing sustainability issues and works towards innovative digital solutions to address these grand challenges. DS Hub proposes a two-fold research approach to generate knowledge and digital solutions for entrepreneurship, new working models, industry transformation, urban policy, and business ecosystems. First, by conducting evidence-based research, the Hub strives to spur empirical advances by building on top of the theoretical foundation of DS. Second, by applying innovative thinking, the Hub endeavours to develop and deploy digital artefacts that positively impact sustainable development. Ultimately, DS Hub’s goal is to be capable of developing and practising digital sustainability research, teaching, knowledge dissemination and engagement.